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Every study, trial, and device Tinnitus Monthly has covered, with the source it came from. Search by topic, treatment, country, journal, or trial number.

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October 2026 · The Evidence File · Germany · Austria · Netherlands · Europe-wide trial

AC102: A Promising New Approach to Treating Tinnitus

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An experimental drug from Berlin’s AudioCure Pharma, injected once into the middle ear, restored damaged inner-ear synapses in noise-exposed gerbils; at five weeks, 1 of 15 treated animals still showed tinnitus behavior versus 11 of 13 controls. A first human trial in 42 volunteers found it safe. The Phase 2 trial, for sudden hearing loss, is listed as ended in January 2026 with no results published. Unproven for tinnitus in people, and unstudied for chronic tinnitus.

Sources: Tziridis K et al., “A Single Dose of AC102 Reverts Tinnitus by Restoring Ribbon Synapses in Noise-Exposed Mongolian Gerbils,” International Journal of Molecular Sciences, 2025 — doi:10.3390/ijms26115124 · Phase 1 study, Otology & Neurotology, 2025 — doi:10.1097/MAO.0000000000004568 · AudioCure Pharma, ClinicalTrials.gov NCT05776459 / EU 2024-513658-31-00

October 2026 · Living With It · Patient report

The Tinnitus Relief I Discovered by Accident

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Primidone, a decades-old drug for seizures and essential tremor, gave me temporary tinnitus relief. Taken daily, the effect faded within a week; a Monday-Wednesday-Friday schedule at 50 mg, worked out with my doctor, has kept it working. Not a cure, and not proven — a patient’s report and a request for doctors to look again.

Sources: Shea JJ, Emmett JR, “The medical treatment of tinnitus,” J Laryngol Otol Suppl, 1981 — PubMed 6946161 · Emmett JR, Shea JJ, Otolaryngol Head Neck Surg, 1980 — PubMed 6821429

September 2026 · Living With It · Essay

The Invisible Illness of Tinnitus: The Loneliness Nobody Sees

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Tinnitus is invisible in the medical sense — your doctor knows you have it because you told him. It is also invisible socially, and that is the part that shapes a life. On the loneliness that does not require being alone, why withdrawing appears to make the sound worse, and what can be done about the loop.

Sources: Pryce H et al., “What is the burden of tinnitus?” Frontiers in Psychology, 2023 — doi:10.3389/fpsyg.2022.981776 · Beukes EW et al., Frontiers in Public Health, 2020 — doi:10.3389/fpubh.2020.592878 · Weisz N et al., Journal of Neuroscience, 2007 — doi:10.1523/JNEUROSCI.3711-06.2007

September 2026 · The Evidence File · Brazil · Germany · Argentina · United States

The Oxytocin Trial That Never Reported

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Two small 2017 studies suggested intranasal oxytocin might reduce tinnitus distress. The confirmatory trial at NYU Langone enrolled 33 people, was terminated when the principal investigator left the institution, and reported no data at all. Nine years on there is still no replication — unproven, which is not the same as disproven.

Sources: Azevedo AA et al., “Tinnitus Treatment with Oxytocin: A Pilot Study,” Frontiers in Neurology, 2017 — doi:10.3389/fneur.2017.00494 · NYU Langone Health, ClinicalTrials.gov NCT04210310 (terminated).

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